England have made an impressive start to the 2018 Six Nations but they face their toughest test of the series at Murrayfield on February 24. Scotland haven’t managed to get their hands on the Calcutta Cup since 2008 and Gregor Townsend will hope his side can find a way of upsetting their neighbours. Eddie Jones’ side inflicted a miserable 61-21 defeat on their opponents when these sides met at Twickenham last year but it’s unlikely to be as clear-cut this time around. Scotland may have opened with an unexpected defeat to Wales but they looked far more compact against France, running out 36-26 winners and it gives them plenty of build upon. The hosts have been priced up as the 40/17 outsiders by 888sport and are 7/8 to keep it tight and cover the +7 handicap. The Scots often tend to fare better when they are regarded as the underdogs and former lock Doddie Weir believes this is their best chance to wrestle back the Calcutta Cup. England have been defeated just once in 14 Six Nations matches and Eddie Jones has made his side incredibly difficult to break down. They welcome back James Haskell and Nathan Jones for this fixture but Sam Simmonds will miss the match after sustaining a shoulder injury against Wales. Ireland Aiming to Make Home Advantage Pay Against Wales Joe Schmidt has an excellent record at the Aviva Stadium having guided his side to ten victories from eleven in the Six Nations. Ireland are aiming to continue that impressive run and build on back-to-back successes in this year’s tournament when they host Wales on February 24. Wales come off the back of a 12-6 defeat at Twickenham but remain the only side to have taken points away from the Aviva Stadium in recent years and will be confident of springing a surprise. The hosts start as 1/4 favourites for this clash but it won’t be easy against a determined Welsh side who will be eager to bounce back from that disappointment in West London a fortnight ago.