The biggest game of the weekend sees two of last week’s big winners come together at Twickenham. Warren Gatland has named an unchanged side for this fixture despite George North’s return to fitness.Despite being written off by many pundits, Wales were rampant against Scotland emerging 34-7 winners but this is set to be much tougher. The Welsh are 4/1 outsiders with NetBet for this game and can be backed at around evens with an eleven-point head start on the handicap market. They have been preparing for this match meticulously and have concentrated on their defensive work as they fully expected the English back-line to cause them problems throughout. Eddie Jones’ side will be without Ben Youngs, who sustained a horrible looking knee injury and is likely to be sidelined until the end of the month. Richard Wigglesworth has been drafted in as his replacement. France travel to Murrayfield on Feburary 11 as the 2/1 outsiders for the clash. Both sides were defeated in their opening encounters and this could be a pivotal tie in helping decide which of these two teams avoids the wooden spoon. The visitors have a good record at this ground having won three of their last four visits here and will be hoping to improve that already-impressive statistic. Ireland Should Maintain Their Excellent Record Against Italy Ireland got their Six Nations campaign off to a winning start on February 3 with a narrow success over France. They will be aiming to make it successive victories and Joe Schmidt’s side are heavily fancied to triumph over a beleaguered Italy. The Irish have been priced up as 1/40 shots for this encounter although a more palatable 10/11 is available with Sporting Bet for the hosts to win by 30 points or more. Italy suffered a thumping defeat to England during their opening game and they have a terrible record against this opposition. During their last two Six Nations meetings with the Italians, Ireland have accumulated 122 points, whilst the visitors have failed to clock up more than 15 points during any of their last six visits to this stadium. It was always going to be a difficult start against the defending champions, but facing Ireland in front of a partisan crowd isn’t much easier for the visiting side.