San Francisco 49ers vs Los Angeles Chargers: Predictions, Odds and Betting Tips

NFL San Francisco 49ers vs Los Angeles Chargers
NFL San Francisco 49ers vs Los Angeles Chargers
Sunday, September 30, 4:25 pm Eastern Time

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The Chargers look to bounce back from a defeat at the hands of their Los Angeles counterparts a week ago, while San Francisco tries to keep the train rolling after losing signal-caller Garoppolo for the year.


The Chargers are coming off a disappointing loss, but the team still has a lot of promise. Second-year wide receiver Mike Williams seems to be coming into his own as he has 3 touchdowns over the first 3 weeks of the season. Williams should have another impressive outing facing off against a Richard Sherman-less secondary for San Francisco.

Backup running back Austin Ekeler has been playing like anything but a backup, and should play a major role come Sunday. Ekeler’s speed out of the backfield will likely be shadowed by 49ers’ sideline-to-sideline linebacker Reuben Foster. This could potentially give us one of the most intriguing player matchups of the weekend.  

The 49ers were overhyped to begin with, but the loss of Garoppolo leaves little hype to be had. CJ Beathard takes the reins at quarterback, and while he is capable of moving an offense, the 9ers lack the skill talent for Beathard to shine. One bright spot for the offense has been running back Matt Breida, who was pushed into starter duty because of a Jerick Mckinnon’s injury, and has responded by leading the NFL in rushing yards. Unfortunately Breida is questionable for Sunday’s game with a knee injury.  If Breida can’t go, that leaves wideout Marquise Goodwin and tight end George Kittle as the only reliable talent for Beathard to lean on. 

The Chargers have been explosive all season, and should have their way with a defense in San Francisco that has surrendered the 6th most ppg this season.

Score prediction: Chargers win 30-13

Betting Tips

While 10.5 is a lot of points, the 49ers are a broken team at the moment. They have injuries up and down their roster, and most recently lost their face of the franchise for the year. San Francisco lacks the firepower to keep pace with an offense that has the 5th most yards in the NFL this season.

Mike Williams and Keenan Allen should shine, as the Chargers will pick on San Francisco’s corners with Richard Sherman out. LA has the talent to light up the scoreboard, and San Fran doesn’t look to have enough juice offensively to respond.


Head to Head

Over the last 6 games LA holds a 4-2 advantage over SF. The Chargers have swept the 49ers in the last 3 games, outpacing them in all statistical categories besides rushing yards.


  • SF is 2-4 ATS (against the spread) in last 6 games.
  • The total has gone UNDER in 4 of SF’s last 6 road games.
  • LA is 7-3 SU (straight up) in last 10 games.
  • LA is 4-1 SU in last 5 games vs. SF.
  • The total has gone UNDER in 10 of LA’s last 14 games.
  • SF RB Matt Breida leads the NFL with 8.6 ypc.
  • LA RB Austin Ekeler ranks second in the NFL with 8.2 ypc.